Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.38 |
| ▸ | EDNRA | P25101 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | EDNRB | P24530 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424082 | 0.92 | SLC22A12 (0.42) | SLC22A12EDNRASMN1; SMN2LMNATSHR | |
| SCHEMBL7427382 | 0.90 | SLC22A12 (0.39) | SLC22A12CHEK2EDNRASMN1; SMN2LMNA | |
| SCHEMBL7418953 | 0.89 | EDNRA (0.39) | SLC22A12CHEK2EDNRAEDNRBCYP1A2 | |
| SCHEMBL7423537 | 0.89 | MEN1 (0.40) | SLC22A12EDNRASMN1; SMN2LMNATSHR | |
| SCHEMBL7426123 | 0.89 | SLC22A12 (0.39) | SLC22A12CHEK2EDNRASMN1; SMN2LMNA | |
| SCHEMBL7426188 | 0.88 | EDNRA (0.38) | SLC22A12CHEK2EDNRAEDNRBCYP1A2 | |
| SCHEMBL7420854 | 0.88 | EDNRA (0.38) | SLC22A12CHEK2EDNRAEDNRBCYP1A2 | |
| SCHEMBL7422738 | 0.88 | EDNRA (0.38) | SLC22A12CHEK2EDNRAEDNRBCYP1A2 | |
| SCHEMBL7420199 | 0.86 | SLC22A12 (0.37) | SLC22A12CHEK2EDNRASMN1; SMN2EDNRB | |
| SCHEMBL7427422 | 0.84 | NPC1 (0.37) | SLC22A12CHEK2EDNRASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |