Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 9/20 | 0.35 |
| ▸ | EDNRB | P24530 | 7/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426123 | 0.89 | SLC22A12 (0.39) | SLC22A12CHEK2EDNRAEDNRBPLA2G2A | |
| SCHEMBL7420485 | 0.86 | ALOX5AP (0.42) | PLA2G2AOXER1MEN1KMT2ACYP1A2 | |
| SCHEMBL7426853 | 0.86 | SLC22A12 (0.40) | SLC22A12CHEK2EDNRAEDNRBPDE4A | |
| SCHEMBL7418953 | 0.83 | EDNRA (0.39) | SLC22A12CHEK2EDNRAEDNRBPDE4A | |
| SCHEMBL7427382 | 0.82 | SLC22A12 (0.39) | SLC22A12CHEK2EDNRAEDNRBPDE4A | |
| SCHEMBL7420854 | 0.81 | EDNRA (0.38) | SLC22A12CHEK2EDNRAEDNRBMEN1 | |
| SCHEMBL7426188 | 0.81 | EDNRA (0.38) | SLC22A12CHEK2EDNRAEDNRBMEN1 | |
| SCHEMBL7422738 | 0.81 | EDNRA (0.38) | SLC22A12CHEK2EDNRAEDNRBMEN1 | |
| SCHEMBL7422706 | 0.81 | SLC22A12 (0.41) | SLC22A12EDNRAEDNRB | |
| SCHEMBL7427422 | 0.81 | NPC1 (0.37) | SLC22A12CHEK2EDNRAEDNRBPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |