Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 2/20 | 0.55 |
| ▸ | MMP2 | P08253 | 2/20 | 0.55 |
| ▸ | MMP9 | P14780 | 2/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430195 | 0.88 | MAOB (0.61) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL7425060 | 0.85 | PTPN1 (0.64) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL7430253 | 0.83 | PTPN1 (0.59) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL7491283 | 0.81 | NPC1 (0.64) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL7426464 | 0.78 | PTPN1 (0.58) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL7370903 | 0.78 | HTR2C (0.70) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL7430969 | 0.77 | PTPN1 (0.56) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL20214140 | 0.77 | NPC1 (0.78) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL7481519 | 0.76 | HTR2C (0.55) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL13352027 | 0.76 | MMP1 (0.74) | NPC1RAB9AMAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000047576-A1 | CINNAMIDE DERIVATIVES AS OREXIN-1 RECEPTORS ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-08-17 | — | — | WO | disclosed |