SCHEMBL7427436

SCHEMBL7427436

CCCCC(NC(=O)c1cccc(NS(=O)(=O)c2ccc3ccccc3c2)c1)C(=O)CNS(C)(=O)=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.45
GGPS1 O95749 1/20 0.44
PLAU P00749 1/20 0.44
ALDH1A1 P00352 1/20 0.43
LMNA P02545 1/20 0.43
GAA P10253 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
KAT6A Q92794 7/20 0.42
AR P10275 1/20 0.42
WDR5 P61964 1/20 0.42
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
ATM Q13315 1/20 0.41
GPR27 Q9NS67 1/20 0.41
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7680584 0.92 AKR1C3 (0.48) AKR1C3GGPS1PLAUALDH1A1LMNA
SCHEMBL7425669 0.91 ALDH1A1 (0.52) AKR1C3PLAUALDH1A1LMNAGAA
SCHEMBL7686060 0.90 EGFR (0.46) PLAUWDR5MEN1KMT2AHDAC3
SCHEMBL7659849 0.90 AKR1C3 (0.47) AKR1C3GGPS1PLAUALDH1A1LMNA
SCHEMBL7658785 0.90 ALDH1A1 (0.45) AKR1C3GGPS1PLAUALDH1A1LMNA
SCHEMBL7694179 0.87 AKR1C3 (0.48) AKR1C3GGPS1PLAUALDH1A1LMNA
SCHEMBL7690188 0.85 EGFR (0.48) PLAUWDR5MEN1KMT2AHDAC3
SCHEMBL7682470 0.83 ALDH1A1 (0.51) AKR1C3PLAUALDH1A1LMNAGAA
SCHEMBL7665000 0.82 ALDH1A1 (0.52) AKR1C3PLAUALDH1A1LMNAGAA
SCHEMBL7428036 0.82 CA2 (0.45) LMNASMN1; SMN2KAT6AHDAC3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6436925-B1 BETTER ABLE TO CROSS MEMBRANES; INHIBITORS OF CYSTEINE PROTEASES LIKE CALPAIN I AND II AND CATHEPSIN B AND L, CAN THUS BE USED TO CONTROL DISEASES ASSOCIATED WITH AN ELEVATED ACTIVITY OF CALPAIN ENZYMES OR CATHEPSIN ENZYMES ABBOTT LABORATORIES 2002-08-20 US disclosed
EP-1073632-A1 SUBSTITUTED BENZAMIDES, THEIR PRODUCTION AND THEIR USE AS CYSTEINE PROTEASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2001-02-07 EP disclosed
WO-1999054293-A1 SUBSTITUTED BENZAMIDES, THEIR PRODUCTION AND THEIR USE AS CYSTEINE PROTEASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1999-10-28 WO disclosed