SCHEMBL7427595

SCHEMBL7427595

Cc1[nH]cnc1CC1CCc2oc3ccccc3c2C1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR3A P46098 4/20 0.38
CYP3A4 P08684 3/20 0.38
KCNH2 Q12809 3/20 0.38
CYP1A2 P05177 2/20 0.38
HTR2B P41595 2/20 0.38
HTR2A P28223 2/20 0.38
ADRA2C P18825 1/20 0.38
HTR2C P28335 1/20 0.38
ADRA1A P35348 1/20 0.38
CASP6 P55212 1/20 0.38
KDM4E B2RXH2 1/20 0.38
CD44 P16070 1/20 0.36
HTR3E A5X5Y0 2/20 0.34
HTR3B O95264 2/20 0.34
HTR3D Q70Z44 2/20 0.34
HTR3C Q8WXA8 2/20 0.34
CYP2D6 P10635 1/20 0.34
SLC22A2 O15244 1/20 0.34
SLC22A1 O15245 1/20 0.34
SLC22A3 O75751 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Maleic Acid SCHEMBL10460281 0.93 HTR3A (0.35) HTR3ACYP3A4KCNH2CYP1A2HTR2B
Fumaric Acid SCHEMBL10460283 0.93 HTR3A (0.35) HTR3ACYP3A4KCNH2CYP1A2HTR2B
SCHEMBL8962746 0.78 HTR3A (0.39) HTR3ACYP3A4KCNH2CYP1A2HTR2B
SCHEMBL9597484 0.77 HTR3A (0.39) HTR3ACYP3A4KCNH2CYP1A2HTR2B
SCHEMBL7430515 0.77 HTR3A (0.38) HTR3ACYP3A4KCNH2CYP1A2HTR2B
Hydrochloric Acid SCHEMBL10460586 0.76 CASP6 (0.39) HTR3ACYP3A4KCNH2CYP1A2HTR2B
Galdansetron SCHEMBL4564582 0.76 KCNH2 (0.61) HTR3ACYP3A4KCNH2CYP1A2HTR2B
Galdansetron SCHEMBL635736 0.76 KCNH2 (0.61) HTR3ACYP3A4KCNH2CYP1A2HTR2B
SCHEMBL7432628 0.76 HSP90AA1 (0.40) CYP3A4ADRA2CADRA1A
Galdansetron SCHEMBL636713 0.75 CASP6 (0.62) HTR3ACYP3A4KCNH2CYP1A2HTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5530008-A USEFUL FOR TREATING ANXIETY DISORDER AND AGORAPHOBIA SANDOZ LTD. (CH) 1996-06-25 US claimed
EP-0422154-B1 THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS SANDOZ AG (AT) 1993-12-01 EP claimed
US-4939144-A PSYCHOLOGICAL DISORDERS; ANXIOLYTIC AND ANTIEMETIC AGENTS GLAXO GROUP LIMITED (GB) 1990-07-03 US claimed
US-5530008-A USEFUL FOR TREATING ANXIETY DISORDER AND AGORAPHOBIA SANDOZ LTD. (CH) 1996-06-25 US disclosed
EP-0422154-B1 THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS SANDOZ AG (AT) 1993-12-01 EP disclosed
EP-0422154-A1 THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS. SANDOZ AG (AT) 1991-04-17 EP disclosed
WO-1990012569-A1 THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS SANDOZ AG (CH) 1990-11-01 WO disclosed
US-4939144-A PSYCHOLOGICAL DISORDERS; ANXIOLYTIC AND ANTIEMETIC AGENTS GLAXO GROUP LIMITED (GB) 1990-07-03 US disclosed
EP-0317088-A1 Ketone derivatives GLAXO GROUP LIMITED (GB) 1989-05-24 EP disclosed