Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.54 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | JAK1 | P23458 | 4/20 | 0.41 |
| ▸ | TYK2 | P29597 | 4/20 | 0.41 |
| ▸ | JAK3 | P52333 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740741 | 1.00 | HRH1 (0.54) | HRH1CHRM1RENJAK2JAK1 | |
| SCHEMBL742774 | 0.92 | HRH1 (0.54) | HRH1CHRM1RENMAPTTP53 | |
| SCHEMBL742773 | 0.92 | HRH1 (0.54) | HRH1CHRM1RENMAPTTP53 | |
| SCHEMBL741971 | 0.89 | HRH1 (0.53) | HRH1CHRM1RENJAK2JAK1 | |
| SCHEMBL741972 | 0.89 | HRH1 (0.53) | HRH1CHRM1RENJAK2JAK1 | |
| SCHEMBL739843 | 0.85 | HRH1 (0.70) | HRH1CHRM1RENKCNH2BRD4 | |
| SCHEMBL739842 | 0.85 | HRH1 (0.70) | HRH1CHRM1RENKCNH2BRD4 | |
| SCHEMBL741000 | 0.84 | CHRM1 (0.49) | HRH1CHRM1RENJAK2JAK1 | |
| SCHEMBL741001 | 0.84 | CHRM1 (0.49) | HRH1CHRM1RENJAK2JAK1 | |
| Piperidine SCHEMBL742276 | 0.83 | HRH1 (0.67) | HRH1CHRM1RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |