Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 6/20 | 0.53 |
| ▸ | LARS1 | Q9P2J5 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5098782 | 1.00 | CACNA1B (0.53) | CACNA1BLARS1CYP2C19MMP2LMNA | |
| SCHEMBL5105401 | 0.90 | CACNA1B (0.47) | CACNA1BMMP2LMNAALDH1A1 | |
| SCHEMBL5092886 | 0.89 | CACNA1B (0.57) | CACNA1BLARS1LMNAALDH1A1 | |
| SCHEMBL5105633 | 0.89 | ALDH1A1 (0.49) | CACNA1BLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7427831 | 0.88 | CACNA1B (0.53) | CACNA1BLMNAALDH1A1 | |
| SCHEMBL4686499 | 0.86 | CTSK (0.49) | CACNA1B | |
| SCHEMBL5971807 | 0.86 | CTSK (0.49) | CACNA1B | |
| SCHEMBL14131846 | 0.85 | CACNA1B (0.42) | CACNA1BLARS1MMP2 | |
| SCHEMBL5096704 | 0.85 | CACNA1B (0.42) | CACNA1BLARS1MMP2 | |
| SCHEMBL5105253 | 0.83 | CACNA1B (0.45) | CACNA1BLARS1LMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | claimed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | claimed |
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | disclosed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |