Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16792376 | 0.89 | MAPT (0.61) | MAPTMERTKVCAM1ALDH1A1TSHR | |
| SCHEMBL31176850 | 0.89 | MAPT (0.61) | MAPTMERTKVCAM1ALDH1A1TSHR | |
| SCHEMBL31009358 | 0.84 | AR (0.49) | MAPTMERTKVCAM1ALDH1A1MEN1 | |
| SCHEMBL6578552 | 0.82 | MERTK (0.53) | MAPTMERTKVCAM1ALDH1A1PDE4A | |
| SCHEMBL31176940 | 0.81 | MAPT (0.49) | MAPTMERTKVCAM1ALDH1A1TSHR | |
| SCHEMBL20982744 | 0.81 | MAPT (0.49) | MAPTMERTKVCAM1ALDH1A1TSHR | |
| SCHEMBL16792385 | 0.81 | MERTK (0.55) | MAPTMERTKVCAM1ALDH1A1TSHR | |
| SCHEMBL2271210 | 0.81 | SMN1; SMN2 (0.54) | MAPTALDH1A1TSHRCYP3A4RECQL | |
| SCHEMBL7429410 | 0.80 | ALDH1A1 (0.61) | MAPTMERTKVCAM1ALDH1A1PDE4A | |
| SCHEMBL18165808 | 0.79 | PDE4A (0.48) | MAPTPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107954-A1 | 2-OXO-$i(2H)-QUINOLINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012479-A1 | 2-OXO-2H-QUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-03-09 | — | — | WO | disclosed |