Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 9/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.38 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420327 | 0.92 | ALOX5AP (0.46) | ALOX5APLMNAHTTDPP4KCNH2 | |
| SCHEMBL7423106 | 0.89 | ALOX5AP (0.42) | ALOX5APDPP4KCNH2L3MBTL1SLC16A3 | |
| SCHEMBL7428819 | 0.84 | ALOX5AP (0.47) | ALOX5APDPP4L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL7420321 | 0.83 | ALOX5AP (0.48) | ALOX5APDPP4L3MBTL1TSHRKDM4E | |
| SCHEMBL7468891 | 0.81 | MAPT (0.44) | ALOX5APLMNADPP4L3MBTL1TSHR | |
| SCHEMBL7707842 | 0.77 | ALOX5AP (0.45) | ALOX5APDPP4L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL7468888 | 0.77 | F2RL3 (0.38) | ALOX5APL3MBTL1TSHRKDM4ETNF | |
| SCHEMBL7417850 | 0.77 | L3MBTL1 (0.40) | ALOX5APL3MBTL1TSHRKDM4ETNF | |
| SCHEMBL7428018 | 0.77 | ALOX5AP (0.44) | ALOX5APDPP4KCNH2SLC16A3SLC16A1 | |
| SCHEMBL7427533 | 0.76 | ALOX5AP (0.46) | ALOX5APDPP4L3MBTL1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |