Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 12/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.34 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.34 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420327 | 0.83 | ALOX5AP (0.46) | ALOX5APDPP4KCNH2SLC16A3SLC16A1 | |
| SCHEMBL8554083 | 0.81 | ALOX5AP (0.43) | ALOX5APDPP4KCNH2F2RL3ALDH1A1 | |
| SCHEMBL7428288 | 0.77 | ALOX5AP (0.47) | ALOX5APDPP4KCNH2MEN1ALDH1A1 | |
| SCHEMBL7428583 | 0.74 | ALOX5AP (0.45) | ALOX5APDPP4MEN1ALDH1A1KMT2A | |
| SCHEMBL7423106 | 0.73 | ALOX5AP (0.42) | ALOX5APDPP4KCNH2MEN1ALDH1A1 | |
| SCHEMBL6170454 | 0.72 | ALOX5AP (0.55) | ALOX5APMEN1ALDH1A1KMT2A | |
| SCHEMBL7422715 | 0.71 | SLC22A12 (0.42) | ALOX5APDPP4MEN1ALDH1A1KMT2A | |
| SCHEMBL7423371 | 0.70 | ALDH1A1 (0.41) | ALOX5APDPP4MEN1ALDH1A1KMT2A | |
| SCHEMBL7416354 | 0.69 | MAPT (0.43) | DPP4F2RL3MEN1ALDH1A1KMT2A | |
| SCHEMBL7707842 | 0.68 | ALOX5AP (0.45) | ALOX5APDPP4MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |