Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 9/20 | 0.54 |
| ▸ | CNR2 | P34972 | 9/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.51 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430775 | 1.00 | CNR1 (0.54) | CNR1CNR2HTTNPSR1CACNA2D1 | |
| SCHEMBL7391005 | 0.84 | CACNA2D1 (0.54) | CACNA2D1CACNA1BCACNB1CACNA1CPOLB | |
| SCHEMBL7425100 | 0.84 | CACNA2D1 (0.54) | CACNA2D1CACNA1BCACNB1CACNA1CPOLB | |
| SCHEMBL7664625 | 0.83 | CNR1 (0.48) | CNR1CNR2HTTNPSR1CACNA2D1 | |
| SCHEMBL7664633 | 0.83 | CNR1 (0.48) | CNR1CNR2HTTNPSR1CACNA2D1 | |
| SCHEMBL7392303 | 0.79 | CACNA2D1 (0.50) | CACNA2D1CACNA1BCACNB1CACNA1CPOLB | |
| SCHEMBL7659212 | 0.79 | CACNA2D1 (0.50) | CACNA2D1CACNA1BCACNB1CACNA1CPOLB | |
| SCHEMBL7391221 | 0.78 | DPP8 (0.62) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL7391223 | 0.78 | DPP8 (0.62) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 | |
| SCHEMBL28829561 | 0.78 | MMP1 (0.51) | GAAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999055688-A1 | SUBSTITUTED DIARYLALKYL AMIDES AS CALCIUM CHANNEL ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-11-04 | — | — | WO | claimed |
| US-6458781-B1 | BLOCKERS CALCIUM CHANNEL ANTAGONISTS FOR STROKES, BRAIN DISORDERS | WARNER-LAMBERT COMPANY | 2002-10-01 | — | — | US | disclosed |
| WO-1999055688-A1 | SUBSTITUTED DIARYLALKYL AMIDES AS CALCIUM CHANNEL ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-11-04 | — | — | WO | disclosed |