Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 5/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.38 |
| ▸ | CBX7 | O95931 | 2/20 | 0.37 |
| ▸ | CDYL | Q9Y232 | 2/20 | 0.37 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.37 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427902 | 0.83 | PGR (0.50) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7307647 | 0.74 | MAPK14 (0.52) | GSK3BPTPN1SMN1; SMN2ALDH1A1PGR | |
| SCHEMBL12467513 | 0.74 | HDAC6 (0.53) | USP2F2L3MBTL1GSK3BPTPN1 | |
| SCHEMBL24427943 | 0.71 | ALDH1A1 (0.53) | PDE3BPDE3AUSP2F2L3MBTL1 | |
| SCHEMBL7379550 | 0.70 | PGR (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL31117105 | 0.70 | PGR (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL5680486 | 0.69 | PGR (0.50) | PDE3BPDE3AUSP2F2L3MBTL1 | |
| SCHEMBL7836579 | 0.68 | PDK2 (0.60) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL507553 | 0.67 | PGR (0.48) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL12620633 | 0.66 | CYP3A4 (0.49) | GSK3BPTPN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933336-A | Thiadiazinone, oxadiazinone and triazinone derivatives, and their use for treating acute or chronic heart disease | LABORATOIRES SOBIO S.A. (FR) | 1990-06-12 | — | — | US | disclosed |
| EP-0303418-A2 | Substituted indolones, useful in the treatment of heart or asthmatic diseases | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1989-02-15 | — | — | EP | disclosed |