Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.64 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | RORC | P51449 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18132382 | 0.89 | ALDH1A1 (0.62) | MAPK8RORCLMNAALDH1A1KDM4E | |
| SCHEMBL28926532 | 0.85 | RORC (0.49) | MAPK8RORCLMNAALDH1A1KDM4E | |
| SCHEMBL3628197 | 0.84 | SIRT2 (0.70) | MAPK8SIRT2LMNAALDH1A1KDM4E | |
| SCHEMBL12700241 | 0.82 | HPGD (0.70) | MAPK8RORCLMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL8636891 | 0.81 | NPC1 (0.64) | MAPK8SIRT2LMNAALDH1A1KDM4E | |
| SCHEMBL8643674 | 0.78 | KMT2A (0.69) | MAPK8SIRT2LMNAALDH1A1KDM4E | |
| SCHEMBL4646586 | 0.77 | MAPK9 (0.63) | SIRT2MAPK10 | |
| SCHEMBL20083575 | 0.76 | IDO1 (0.67) | MAPK8RORCLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9448420 | 0.75 | NPC1 (0.59) | LMNAALDH1A1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL5443977 | 0.75 | RORC (0.72) | RORCLMNAALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200976-B1 | FOR TREATING THROMBOSIS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-13 | — | — | US | disclosed |
| EP-1071669-A1 | BICYCLIC COMPOUNDS HAVING AN ANTI-THROMBITIC EFFECT | Boehringer Ingelheim Pharma KG (DE) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999054313-A1 | BICYCLIC COMPOUNDS HAVING AN ANTI-THROMBITIC EFFECT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-28 | — | — | WO | disclosed |