Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Enalkiren SCHEMBL123107 | 0.85 | REN (0.62) | REN | |
| SCHEMBL7335979 | 0.83 | REN (0.53) | REN | |
| SCHEMBL7334721 | 0.79 | REN (0.52) | REN | |
| SCHEMBL9523860 | 0.79 | REN (0.46) | REN | |
| SCHEMBL13754442 | 0.77 | REN (0.65) | REN | |
| SCHEMBL7316219 | 0.76 | REN (0.41) | REN | |
| SCHEMBL7334725 | 0.76 | REN (0.42) | REN | |
| Enalkiren SCHEMBL123108 | 0.76 | REN (0.69) | REN | |
| Hydrochloric Acid SCHEMBL7318517 | 0.76 | REN (0.41) | REN | |
| SCHEMBL7326151 | 0.75 | REN (0.60) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10668049-B2 | Methods of treating cognitive decline with transforming growth factor beta inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-06-02 | — | — | US | disclosed |
| US-20160367530-A1 | METHODS OF TREATING NEUROLOGICAL DISORDERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-12-22 | — | — | US | disclosed |
| US-9468649-B2 | Methods of treating epilepsy with transforming growth factor beta inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-10-18 | — | — | US | disclosed |
| EP-0634175-B1 | Pharmaceutical combination, containing a renin-angiotensin-system inhibitor and an endothelin antagonist | HOFFMANN LA ROCHE (CH) | 2001-01-10 | — | — | EP | disclosed |
| EP-0425892-A2 | Process for enhancing the bioavailability of drugs with peptide bonds | BASF Aktiengesellschaft (DE) | 1991-05-08 | — | — | EP | disclosed |