Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.52 |
| ▸ | METAP2 | P50579 | 5/20 | 0.46 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 4/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10587950 | 1.00 | REN (0.52) | RENMETAP2CPB2METAP1MMP2 | |
| SCHEMBL9831134 | 0.88 | REN (0.51) | RENMETAP2CPB2METAP1MMP2 | |
| SCHEMBL10608625 | 0.88 | REN (0.51) | RENMETAP2CPB2METAP1MMP2 | |
| Hydrochloric Acid SCHEMBL9832396 | 0.87 | REN (0.50) | RENMETAP2CPB2METAP1MMP2 | |
| SCHEMBL10611293 | 0.83 | REN (0.53) | RENMETAP2CPB2METAP1 | |
| SCHEMBL7430587 | 0.83 | REN (0.48) | RENMETAP2CPB2METAP1CTSK | |
| SCHEMBL7270757 | 0.81 | REN (0.51) | RENMETAP2CPB2METAP1MMP8 | |
| SCHEMBL7270755 | 0.81 | REN (0.51) | RENMETAP2CPB2METAP1MMP8 | |
| SCHEMBL10608861 | 0.79 | REN (0.50) | RENMETAP2CPB2METAP1 | |
| SCHEMBL3564204 | 0.79 | REN (0.68) | RENMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5346887-A | Mixture of tripeptide renin inhibitor and steroid antiinflammatory agent | ABBOTT LABORATORIES (US) | 1994-09-13 | — | — | US | disclosed |
| US-5059589-A | Glaucoma treatment | ABBOTT LABORATORIES (US) | 1991-10-22 | — | — | US | disclosed |
| US-5036051-A | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-07-30 | — | — | US | disclosed |
| US-4927807-A | RENIN INHIBITING AMIDES | ABBOTT LABORATORIES (US) | 1990-05-22 | — | — | US | disclosed |
| EP-0311012-A2 | Glaucoma treatment | ABBOTT LABORATORIES (US) | 1989-04-12 | — | — | EP | disclosed |