Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.48 |
| ▸ | METAP2 | P50579 | 7/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | METAP1 | P53582 | 6/20 | 0.38 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10587950 | 0.83 | REN (0.52) | RENMETAP2CTSKMETAP1CPB2 | |
| SCHEMBL7428457 | 0.83 | REN (0.52) | RENMETAP2CTSKMETAP1CPB2 | |
| SCHEMBL10611293 | 0.82 | REN (0.53) | RENMETAP2METAP1CPB2ALDH1A1 | |
| SCHEMBL9831134 | 0.82 | REN (0.51) | RENMETAP2METAP1CPB2ALDH1A1 | |
| SCHEMBL10608625 | 0.82 | REN (0.51) | RENMETAP2METAP1CPB2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9832396 | 0.81 | REN (0.50) | RENMETAP2METAP1CPB2ALDH1A1 | |
| SCHEMBL10608861 | 0.78 | REN (0.50) | RENMETAP2METAP1CPB2ALDH1A1 | |
| SCHEMBL10611167 | 0.77 | REN (0.49) | RENMETAP2METAP1CPB2ALDH1A1 | |
| SCHEMBL10608867 | 0.75 | REN (0.58) | RENMETAP2METAP1CPB2ALDH1A1 | |
| SCHEMBL3564204 | 0.73 | REN (0.68) | RENMETAP2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5346887-A | Mixture of tripeptide renin inhibitor and steroid antiinflammatory agent | ABBOTT LABORATORIES (US) | 1994-09-13 | — | — | US | disclosed |
| US-5059589-A | Glaucoma treatment | ABBOTT LABORATORIES (US) | 1991-10-22 | — | — | US | disclosed |
| US-5036051-A | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-07-30 | — | — | US | disclosed |
| US-4927807-A | RENIN INHIBITING AMIDES | ABBOTT LABORATORIES (US) | 1990-05-22 | — | — | US | disclosed |
| EP-0311012-A2 | Glaucoma treatment | ABBOTT LABORATORIES (US) | 1989-04-12 | — | — | EP | disclosed |