Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16883484 | 0.83 | PTPN1 (0.61) | SMN1; SMN2KDM4EHPGDPTPN1ALDH1A1 | |
| SCHEMBL28491600 | 0.82 | NR1H4 (0.56) | SMN1; SMN2KDM4EHPGDPTPN1ALDH1A1 | |
| SCHEMBL20245173 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EHPGDPTPN1ALDH1A1 | |
| SCHEMBL2774094 | 0.81 | SMN1; SMN2 (0.72) | SMN1; SMN2KDM4EHPGDPTPN1ALDH1A1 | |
| SCHEMBL22570671 | 0.81 | PTPN1 (0.54) | SMN1; SMN2KDM4EHPGDPTPN1ALDH1A1 | |
| SCHEMBL1974978 | 0.80 | PTPN1 (0.71) | SMN1; SMN2KDM4EHPGDPTPN1ALDH1A1 | |
| SCHEMBL29489791 | 0.80 | PTPN1 (0.71) | SMN1; SMN2KDM4EHPGDPTPN1ALDH1A1 | |
| SCHEMBL28503641 | 0.79 | NR1H4 (0.60) | KDM4EHPGDPTPN1ALDH1A1NPC1 | |
| SCHEMBL20245171 | 0.78 | HDAC1 (0.52) | SMN1; SMN2KDM4EHPGDPTPN1ALDH1A1 | |
| SCHEMBL1945591 | 0.78 | MTNR1A (0.59) | SMN1; SMN2KDM4EHPGDPTPN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4453003-A | ENZYME INHIBITORS, ANTIINFLAMMATORY AGENTS | UMEZAWA HAMAO (JP) | 1984-06-05 | — | — | US | disclosed |
| US-4391986-A | Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediates therefor and process for producing them | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1983-07-05 | — | — | US | disclosed |
| US-4281180-A | Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediated therefor and process for producing them | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1981-07-28 | — | — | US | disclosed |