Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903610 | 0.85 | TAAR1 (0.43) | TAAR1KCNN4MAPK1CYP2C19HIF1A | |
| SCHEMBL6570649 | 0.80 | TAAR1 (0.43) | TAAR1KCNN4MAPK1CYP2C19HIF1A | |
| SCHEMBL1059140 | 0.74 | KCNN4 (0.48) | TAAR1KCNN4MAPK1CYP2C19HIF1A | |
| SCHEMBL3698483 | 0.73 | TAAR1 (0.44) | TAAR1KCNN4MAPK1CYP2C19HIF1A | |
| SCHEMBL1287614 | 0.73 | TAAR1 (0.44) | TAAR1KCNN4MAPK1CYP2C19HIF1A | |
| SCHEMBL7932124 | 0.73 | TAAR1 (0.44) | TAAR1KCNN4MAPK1CYP2C19HIF1A | |
| SCHEMBL9579241 | 0.71 | TAAR1 (0.43) | TAAR1KCNN4MAPK1CYP2C19HIF1A | |
| SCHEMBL1244899 | 0.71 | ESR1 (0.43) | TAAR1KCNN4MAPK1CYP2C19HIF1A | |
| SCHEMBL1720942 | 0.70 | TAAR1 (0.58) | TAAR1KCNN4MAPK1CYP2C19HIF1A | |
| SCHEMBL4249887 | 0.70 | TAAR1 (0.46) | TAAR1KCNN4MAPK1CYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1127049-A1 | BRIDGED HETEROCYCLIC DERIVATIVES | GPI NIL Holdings, Inc. (US) | 2001-08-29 | — | — | EP | disclosed |
| US-6140357-A | STIMULATING GROWTH OF DAMAGED PERIPHERAL NERVES BY ADMINISTERING TO DAMAGED PERIPHERAL NERVES NEUROTROPHIC N-GLYOXYLPROLYL ESTER COMPOUNDHAVING AN AFFINITY FOR IMMUNOPHILINS | GPI NIL HOLDINGS, INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-1011650-A1 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | Amgen Inc., (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-2000016603-A2 | BRIDGED HETEROCYCLIC DERIVATIVES | GPI NIL HOLDINGS, INC. (US) | 2000-03-30 | — | — | WO | disclosed |
| WO-1999014998-A2 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | AMGEN INC. (US) | 1999-04-01 | — | — | WO | disclosed |
| US-5859031-A | Small molecule inhibitors of rotamase enzyme activity | GPI NIL HOLDINGS, INC. (US) | 1999-01-12 | — | — | US | disclosed |
| US-5795908-A | FKBP IMMUNOPHILINS FOR ENZYME INHIBITORS | GPI NIL HOLDINGS, INC. (US) | 1998-08-18 | — | — | US | disclosed |