Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26852809 | 0.80 | SIGMAR1 (0.41) | SIGMAR1HTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL9515103 | 0.78 | SIGMAR1 (0.43) | SIGMAR1HTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL7852383 | 0.73 | MAPK1 (0.46) | SIGMAR1HTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL7858278 | 0.73 | MAPK1 (0.46) | SIGMAR1HTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL7852382 | 0.73 | MAPK1 (0.46) | SIGMAR1HTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL24210480 | 0.70 | KDM1A (0.39) | MAPK1SMN1; SMN2CHRM2CHRM4CHRM5 | |
| SCHEMBL11015570 | 0.70 | HTR2A (0.41) | SIGMAR1HTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL10446610 | 0.68 | SIGMAR1 (0.42) | SIGMAR1HTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL28268454 | 0.67 | HTR2A (0.36) | SIGMAR1HTR2AHTR2CHTR2BKDM1A | |
| SCHEMBL11698841 | 0.67 | SIGMAR1 (0.41) | SIGMAR1HTR2AHTR2CHTR2BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268148-A1 | Tetrahydronaphthalene derivatives and medicaments containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1988-05-25 | — | — | EP | disclosed |