Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7621739 | 0.78 | KDM1A (0.39) | MAPK1SMN1; SMN2KDM1AMAOB | |
| SCHEMBL7428779 | 0.78 | SIGMAR1 (0.39) | SIGMAR1HTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL7852383 | 0.76 | MAPK1 (0.46) | SIGMAR1HTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL7858278 | 0.76 | MAPK1 (0.46) | SIGMAR1HTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL7852382 | 0.76 | MAPK1 (0.46) | SIGMAR1HTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL10446610 | 0.74 | SIGMAR1 (0.42) | SIGMAR1HTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL28268454 | 0.73 | HTR2A (0.36) | SIGMAR1HTR2AHTR2CHTR2BKDM1A | |
| SCHEMBL24210480 | 0.73 | KDM1A (0.39) | MAPK1SMN1; SMN2KDM1AMAOBCHRM2 | |
| SCHEMBL11698841 | 0.73 | SIGMAR1 (0.41) | SIGMAR1HTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL11015570 | 0.73 | HTR2A (0.41) | SIGMAR1HTR2AHTR2CHTR2BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0378456-B1 | TETRALIN DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-09-15 | — | — | EP | disclosed |
| US-5106861-A | Method of using certain tetralin derivatives to produce analgesic relief | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-04-21 | — | — | US | disclosed |
| US-5041673-A | Aminopeptidase inhibitors, immunomodulators, analgesics | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |
| EP-0378456-A1 | Tetralin derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-07-18 | — | — | EP | disclosed |