Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | RGS17 | Q9UGC6 | 2/20 | 0.38 |
| ▸ | BAD | Q92934 | 2/20 | 0.38 |
| ▸ | RGS12 | O14924 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7431153 | 0.86 | ALDH1A1 (0.38) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| SCHEMBL403982 | 0.73 | BAD (0.49) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| SCHEMBL30400843 | 0.73 | BAD (0.49) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| SCHEMBL70608 | 0.71 | ALDH1A1 (0.33) | ALDH1A1HSD17B10TSHRTDP1 | |
| SCHEMBL7537851 | 0.70 | KDM4E (0.33) | KDM4EMAPTHPGDMEN1KMT2A | |
| SCHEMBL3142725 | 0.69 | CYP3A4 (0.38) | ALDH1A1MAPK1HSD17B10CYP3A4TDP1 | |
| SCHEMBL7533311 | 0.68 | MTNR1A (0.34) | KDM4EHPGDHSD17B10ACHECYP1A2 | |
| SCHEMBL3971384 | 0.68 | KDM4E (0.43) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| SCHEMBL20662 | 0.68 | — | — | |
| SCHEMBL2282037 | 0.67 | HPRT1 (0.39) | ALDH1A1HSD17B10TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283310-B1 | N-BENZHYDRYL-SUBSTITUTED HETEROCYCLIC DERIVATIVES, THEIR PREPARATION AND THEIR USE | Sankyo Company Limited (JP) | 1993-05-26 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| US-5028610-A | Calcium Channel Blockers | SANKYO COMPANY LIMITED (JP) | 1991-07-02 | — | — | US | disclosed |
| EP-0283310-A1 | N-Benzhydryl-substituted heterocyclic derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1988-09-21 | — | — | EP | disclosed |