Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 4/20 | 0.62 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.62 |
| ▸ | CCNC | P24863 | 1/20 | 0.62 |
| ▸ | CDK8 | P49336 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | XBP1 | P17861 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479841 | 0.90 | NTRK1 (0.60) | NTRK1NTRK2CCNCCDK8MAPT | |
| SCHEMBL7476339 | 0.87 | MAPT (0.67) | NTRK1NTRK2MAPTMEN1KMT2A | |
| SCHEMBL7426870 | 0.85 | NTRK1 (0.64) | NTRK1NTRK2CCNCCDK8MAPT | |
| SCHEMBL7427489 | 0.83 | MEN1 (0.58) | NTRK1NTRK2CCNCCDK8MAPT | |
| SCHEMBL5446263 | 0.83 | MAPT (0.63) | MAPTMEN1KMT2ALMNAMITF | |
| SCHEMBL3467864 | 0.82 | MEN1 (0.59) | NTRK1NTRK2CCNCCDK8MAPT | |
| SCHEMBL7479789 | 0.81 | NTRK1 (0.67) | NTRK1NTRK2CCNCCDK8MAPT | |
| SCHEMBL5436652 | 0.77 | BRAF (0.69) | NTRK2CDK8MAPTMEN1KMT2A | |
| SCHEMBL7426341 | 0.77 | MEN1 (0.59) | NTRK1NTRK2CCNCCDK8MAPT | |
| SCHEMBL7481013 | 0.77 | MAPT (0.63) | NTRK1NTRK2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | claimed |
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | disclosed |