Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.69 |
| ▸ | KDR | P35968 | 6/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.69 |
| ▸ | TNNI3K | Q59H18 | 5/20 | 0.69 |
| ▸ | RAF1 | P04049 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | XBP1 | P17861 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5446099 | 0.90 | KDR (0.55) | BRAFKDRMAPK14TNNI3KRAF1 | |
| SCHEMBL5437217 | 0.84 | LMNA (0.69) | RAF1MAPTMEN1HTTKMT2A | |
| SCHEMBL5444618 | 0.83 | RAF1 (0.54) | BRAFKDRMAPK14TNNI3KRAF1 | |
| SCHEMBL5456041 | 0.82 | BRAF (0.49) | BRAFKDRMAPK14TNNI3K | |
| SCHEMBL5454402 | 0.82 | BLM (0.71) | BRAFKDRMAPK14TNNI3KRAF1 | |
| SCHEMBL3177619 | 0.82 | KDR (1.00) | BRAFKDRMAPK14TNNI3KRAF1 | |
| SCHEMBL5446263 | 0.79 | MAPT (0.63) | BRAFKDRMAPK14TNNI3KMAPT | |
| SCHEMBL3171719 | 0.79 | KDR (0.76) | BRAFKDRMAPK14TNNI3KRAF1 | |
| SCHEMBL11865005 | 0.79 | MAPT (0.63) | KDRMAPTMEN1HTTKMT2A | |
| SCHEMBL5444864 | 0.78 | KDM4E (0.47) | BRAFKDRMAPK14TNNI3KRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | MERCK PATENT GMBH (DE) | 2007-08-16 | — | — | US | claimed |
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | MERCK PATENT GMBH (DE) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | RAF1, ARAF, JAK1 | BRAF 4/4885KDR 2178/4885MAPK14 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.