Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8242997 | 0.86 | ALDH1A1 (0.60) | ALDH1A1LMNAKDM4EMAPTHSD11B1 | |
| SCHEMBL8252500 | 0.86 | ALDH1A1 (0.60) | ALDH1A1LMNAKDM4EMAPTHSD11B1 | |
| SCHEMBL14498799 | 0.86 | ALDH1A1 (0.60) | ALDH1A1LMNAKDM4EMAPTHSD11B1 | |
| SCHEMBL15359350 | 0.82 | HTR7 (0.59) | HTR7HSD11B1HRH3KMT2AGAA | |
| SCHEMBL5635944 | 0.81 | HTR7 (0.47) | ALDH1A1HTR7HSD11B1HRH3HCRTR1 | |
| SCHEMBL5637412 | 0.81 | HTR7 (0.47) | ALDH1A1HTR7HSD11B1HRH3HCRTR1 | |
| SCHEMBL1835257 | 0.76 | HRH3 (0.67) | HRH3 | |
| SCHEMBL1833433 | 0.76 | HRH3 (0.67) | HRH3 | |
| SCHEMBL20370207 | 0.73 | GAA (0.76) | ALDH1A1LMNAHSD11B1HRH3KMT2A | |
| SCHEMBL6392322 | 0.73 | NPC1 (0.48) | LMNAKMT2AGAAHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192165-A2 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES | Bristol-Myers Squibb Pharma Company (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000077010-A2 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |