SCHEMBL7429430

SCHEMBL7429430

CC(=O)SCC(CCCc1ccccc1)C(=O)O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIK1 P39086 1/20 0.56
CPB2 Q96IY4 2/20 0.55
MMP2 P08253 3/20 0.47
MMP3 P08254 2/20 0.47
MMP1 P03956 1/20 0.47
MMP9 P14780 1/20 0.47
MMP8 P22894 1/20 0.47
MME P08473 2/20 0.47
FOLH1 Q04609 1/20 0.45
CYP1A2 P05177 2/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
ABCC3 O15438 1/20 0.44
NR1I2 O75469 1/20 0.44
ABCB11 O95342 1/20 0.44
NR3C1 P04150 1/20 0.44
RARG P13631 1/20 0.44
CNR1 P21554 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8167065 0.95 CPB2 (0.57) GRIK1CPB2MMP2MMP3MMP1
SCHEMBL8168663 0.94 CPB2 (0.60) GRIK1CPB2MMP2MMP3MMP1
SCHEMBL6294971 0.91 CPB2 (0.50) GRIK1CPB2MMECYP1A2CYP3A4
SCHEMBL6578378 0.86 CYP2D6 (0.49) GRIK1MMP2MMP3MMEFOLH1
SCHEMBL1856639 0.82 GRIK1 (0.72) GRIK1CPB2MMP2MMP3MMP1
SCHEMBL7076099 0.81 GRIK1 (0.59) GRIK1CPB2MMP2MMP3MMP1
SCHEMBL6578386 0.81 GRIK1 (0.59) GRIK1CPB2MMP2MMP3MMP1
SCHEMBL6154521 0.81 CYP1A2 (0.63) CPB2MMEFOLH1CYP1A2CYP3A4
SCHEMBL838962 0.81 CYP1A2 (0.63) CPB2MMEFOLH1CYP1A2CYP3A4
SCHEMBL838961 0.81 CYP1A2 (0.63) CPB2MMEFOLH1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6048852-A BACTERICIDES SMITHKLINE BEECHAM P.L.C. (GB) 2000-04-11 US disclosed
US-6022885-A Pyrrolidine and thiazole derivatives with antibacterial and . metallo-.beta-lactamase inhibitory properties SMITHKLINE BEECHAM P.L.C. (GB) 2000-02-08 US disclosed
EP-0900197-A1 BETA-THIOPROPIONYL-AMINOACID DERIVATIVES AND THEIR USE AS BETA-LACTAMASE INHIBITORS SMITHKLINE BEECHAM PLC (GB) 1999-03-10 EP disclosed
EP-0850230-A1 PYRROLIDINE AND THIAZOLE DERIVATIVES WITH ANTIBACTERIAL AND METALLO-BETA-LACTAMASE INHIBITORY PROPERTIES SMITHKLINE BEECHAM PLC (GB) 1998-07-01 EP disclosed
WO-1997030027-A1 BETA-THIOPROPIONYL-AMINOACID DERIVATIVES AND THEIR USE AS BETA-LACTAMASE INHIBITORS SMITHKLINE BEECHAM PLC (GB) 1997-08-21 WO disclosed
WO-1997010225-A1 PYRROLIDINE AND THIAZOLE DERIVATIVES WITH ANTIBACTERIAL AND METALLO-BETA-LACTAMASE INHIBITORY PROPERTIES SMITHKLINE BEECHAM PLC (GB) 1997-03-20 WO disclosed
US-5210266-A Analgesic enkephalinase inhibitors DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1993-05-11 US disclosed
US-5179125-A Analgesics DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1993-01-12 US disclosed
EP-0318859-A2 N-substituted mercaptopropanamide derivatives Dainippon Pharmaceutical Co., Ltd. (JP) 1989-06-07 EP disclosed