Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 19/20 | 0.70 |
| ▸ | MMP13 | P45452 | 18/20 | 0.70 |
| ▸ | ADAM17 | P78536 | 18/20 | 0.70 |
| ▸ | MMP1 | P03956 | 17/20 | 0.70 |
| ▸ | MMP2 | P08253 | 4/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4027909 | 0.83 | ADAM17 (1.00) | MMP9MMP13ADAM17MMP1MMP2 | |
| SCHEMBL4033017 | 0.78 | ADAM17 (0.70) | MMP9MMP13ADAM17MMP1MMP2 | |
| SCHEMBL4030080 | 0.76 | ADAM17 (0.82) | MMP9MMP13ADAM17MMP1MMP2 | |
| SCHEMBL7431144 | 0.75 | ADAM17 (0.56) | MMP9MMP13ADAM17MMP1MMP2 | |
| SCHEMBL4024002 | 0.73 | ADAM17 (0.72) | MMP9MMP13ADAM17MMP1MMP2 | |
| SCHEMBL4029298 | 0.72 | MMP9 (0.74) | MMP9MMP13ADAM17MMP1MMP2 | |
| SCHEMBL4027905 | 0.71 | ADAM17 (0.81) | MMP9MMP13ADAM17MMP1MMP2 | |
| SCHEMBL3947121 | 0.71 | ADAM17 (0.66) | MMP9MMP13ADAM17MMP1MMP2 | |
| SCHEMBL6498318 | 0.70 | ADAM17 (0.67) | MMP9MMP13ADAM17MMP1MMP2 | |
| SCHEMBL4023883 | 0.70 | ADAM17 (0.69) | MMP9MMP13ADAM17MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144368-A2 | ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-17 | — | — | EP | claimed |
| WO-2000044709-A2 | ACETYLENIC α-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | claimed |