Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 15/20 | 0.50 |
| ▸ | CTSS | P25774 | 2/20 | 0.48 |
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429577 | 0.85 | REN (0.46) | RENCTSSCTSK | |
| SCHEMBL7440606 | 0.81 | REN (0.44) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7433143 | 0.81 | REN (0.61) | REN | |
| SCHEMBL7428000 | 0.81 | REN (0.61) | RENCTSSCTSKCTSLCTSB | |
| SCHEMBL7435734 | 0.81 | REN (0.46) | RENCTSSCTSK | |
| SCHEMBL3819130 | 0.79 | CTSS (0.61) | RENCTSSCTSKGAAL3MBTL1 | |
| SCHEMBL7350020 | 0.79 | REN (0.61) | RENCTSSCTSK | |
| SCHEMBL7433079 | 0.78 | REN (0.62) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3833311 | 0.78 | CTSS (0.60) | RENCTSSCTSKGAAL3MBTL1 | |
| SCHEMBL5050579 | 0.77 | CTSS (0.56) | RENCTSSCTSKGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1989007940-A1 | 1,2-HYDROXY PHOSPHONATES AND DERIVATIVES THEREOF | E.R. SQUIBB & SONS, INC. (US) | 1989-09-08 | — | — | WO | claimed |
| EP-0331105-A2 | 1,2-Hydroxy phosphonates and derivatives thereof | E.R. Squibb & Sons, Inc. (US) | 1989-09-06 | — | — | EP | claimed |
| US-5217958-A | Hypotensive agents | E. R. SQUIBB & SONS, INC. (US) | 1993-06-08 | — | — | US | disclosed |
| WO-1989007940-A1 | 1,2-HYDROXY PHOSPHONATES AND DERIVATIVES THEREOF | E.R. SQUIBB & SONS, INC. (US) | 1989-09-08 | — | — | WO | disclosed |
| EP-0331105-A2 | 1,2-Hydroxy phosphonates and derivatives thereof | E.R. Squibb & Sons, Inc. (US) | 1989-09-06 | — | — | EP | disclosed |