Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 15/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440606 | 0.88 | REN (0.44) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7423570 | 0.86 | REN (0.47) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7429694 | 0.82 | REN (0.38) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7431784 | 0.77 | REN (0.61) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7436333 | 0.76 | REN (0.46) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7432312 | 0.76 | PSMB5 (0.56) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7312408 | 0.71 | REN (0.43) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7321106 | 0.71 | REN (0.43) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7344132 | 0.71 | REN (0.65) | REN | |
| SCHEMBL7429573 | 0.70 | REN (0.50) | RENPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0331105-A2 | 1,2-Hydroxy phosphonates and derivatives thereof | E.R. Squibb & Sons, Inc. (US) | 1989-09-06 | — | — | EP | disclosed |