Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.68 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.68 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28563290 | 0.86 | CYP2A6 (0.64) | KEAP1NFE2L2CYP2A6CA2HDAC10 | |
| SCHEMBL8253324 | 0.84 | CYP2A6 (0.58) | KEAP1NFE2L2CYP2A6CA2HDAC10 | |
| SCHEMBL8173706 | 0.82 | KEAP1 (0.48) | KEAP1NFE2L2CYP2A6CA2HDAC10 | |
| SCHEMBL30469746 | 0.82 | CYP2A6 (0.55) | KEAP1NFE2L2CYP2A6CA2HDAC10 | |
| SCHEMBL8246357 | 0.82 | CYP2A6 (0.55) | KEAP1NFE2L2CYP2A6CA2HDAC10 | |
| SCHEMBL15897090 | 0.82 | CYP2A6 (0.55) | KEAP1NFE2L2CYP2A6CA2HDAC10 | |
| SCHEMBL8255701 | 0.81 | CYP2A6 (0.58) | KEAP1NFE2L2CYP2A6CA2HDAC10 | |
| SCHEMBL22499949 | 0.81 | KEAP1 (0.68) | KEAP1NFE2L2CA2MAPTPPARD | |
| SCHEMBL1520041 | 0.81 | KEAP1 (1.00) | KEAP1NFE2L2CYP2A6CA2MAPT | |
| SCHEMBL1520186 | 0.81 | KEAP1 (0.68) | KEAP1NFE2L2CA2MAPTUTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228478-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2024-07-11 | — | — | US | disclosed |
| CN-116568677-A | piperidin-1-yl-N-pyridin-3-yl-2-oxoacetamide derivatives useful for the treatment of MTAP deficiency and/or MTA accumulating cancers | 探戈医药股份有限公司 | 2023-08-08 | — | — | CN | disclosed |
| EP-0375451-A2 | Compounds having a renin-inhibiting activity | BEECHAM GROUP PLC (GB) | 1990-06-27 | — | — | EP | disclosed |
| EP-0350163-A2 | Renin inhibitory peptides | BEECHAM GROUP PLC (GB) | 1990-01-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228478-A1 | COMPOUNDS AND METHODS OF USE | F12, C1R, ABCG2 | KEAP1 1708/4885NFE2L2 3140/4885CYP2A6 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.