SCHEMBL7429753

SCHEMBL7429753

CN(C#N)C(=O)N(C(=O)c1ccc(-c2csc(N3CCN(C(=O)OC(C)(C)C)CC3)n2)cc1)C1CCCCC1

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
ALDH1A1 P00352 1/20 0.45
GPR119 Q8TDV5 12/20 0.44
LMNA P02545 2/20 0.43
MAPT P10636 2/20 0.43
TSHR P16473 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
HTT P42858 1/20 0.43
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
CTSB P07858 2/20 0.41
CTSS P25774 2/20 0.41
CTSL P07711 1/20 0.41
CTSK P43235 1/20 0.41
KCNH2 Q12809 1/20 0.41
USP30 Q70CQ3 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6184273 0.87 CTSB (0.49) MAPK1SMN1; SMN2ALDH1A1GPR119LMNA
SCHEMBL7588285 0.82 MAPT (0.45) MAPK1SMN1; SMN2ALDH1A1GPR119LMNA
SCHEMBL1473079 0.77 MAPT (0.58) MAPK1SMN1; SMN2ALDH1A1LMNAMAPT
SCHEMBL7042069 0.76 CTSB (0.51) MAPK1SMN1; SMN2ALDH1A1LMNAMAPT
SCHEMBL6182683 0.76 GPR119 (0.45) GPR119
SCHEMBL6183250 0.75 MAPT (0.44) MAPK1SMN1; SMN2ALDH1A1GPR119LMNA
SCHEMBL6183679 0.74 GPR119 (0.43) GPR119CTSBCTSSCTSLCTSK
SCHEMBL3767565 0.74 MAPT (0.74) MAPK1SMN1; SMN2ALDH1A1LMNAMAPT
SCHEMBL29157428 0.74 MAPT (0.74) MAPK1SMN1; SMN2ALDH1A1LMNAMAPT
SCHEMBL13208949 0.74 MAPT (0.58) MAPK1SMN1; SMN2ALDH1A1GPR119LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001068645-A2 N-CYANOMETHYLCARBOXAMIDES AND THEIR USE AS PROTEASE INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2001-09-20 WO claimed