Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA9 | Q16790 | 3/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425680 | 0.83 | PDE3B (0.43) | PDE3BPDE3APDGFRAMAPK8CDK5 | |
| SCHEMBL7484521 | 0.81 | PDE3B (0.46) | PDE3BPDE3AMAPTKMT2AL3MBTL1 | |
| SCHEMBL7429434 | 0.69 | KMT2A (0.41) | PDE3BPDE3ANAPRTMEN1PSMD14 | |
| SCHEMBL7269315 | 0.68 | PDE3B (0.49) | PDE3BPDE3APDGFRAMAPK8CDK5 | |
| SCHEMBL28338028 | 0.66 | NAPRT (0.50) | NAPRTMEN1MAPTKMT2ACA1 | |
| SCHEMBL2519767 | 0.64 | PDGFRA (0.40) | PDGFRAMAPK8CDK5CLK4MEN1 | |
| SCHEMBL7430671 | 0.60 | PDE3B (0.67) | PDE3BPDE3ANAPRTMEN1KMT2A | |
| SCHEMBL17115264 | 0.59 | KMT2A (0.60) | NAPRTMEN1KMT2AL3MBTL1CA1 | |
| SCHEMBL18951753 | 0.58 | — | — | |
| SCHEMBL623286 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329070-B1 | Cardiotonic alkanoyl and aroyl oxazolones | MERRELL DOW PHARMA (US) | 1994-01-05 | — | — | EP | disclosed |