Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429835 | 0.83 | PDE3B (0.38) | PDE3BPDE3AKMT2AMEN1PDE4A | |
| SCHEMBL7429434 | 0.83 | KMT2A (0.41) | PDE3BPDE3AKMT2AMEN1PDE4A | |
| SCHEMBL7427396 | 0.80 | PDE4A (0.65) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7430671 | 0.71 | PDE3B (0.67) | PDE3BPDE3AKMT2AMEN1PDE4A | |
| SCHEMBL7269315 | 0.69 | PDE3B (0.49) | PDE3BPDE3AKMT2APDE4APDE4B | |
| SCHEMBL2519767 | 0.69 | PDGFRA (0.40) | KMT2AMEN1ALDH1A1PDGFRAMAPK8 | |
| SCHEMBL14565094 | 0.68 | PDE3B (0.60) | PDE3BPDE3AKMT2AMEN1LTA4H | |
| SCHEMBL10605822 | 0.68 | CHRM4 (0.44) | PDE3BPDE3AKMT2AMEN1PDE4A | |
| SCHEMBL725064 | 0.67 | KMT2A (0.80) | KMT2AMEN1LTA4HLMNACYP2C9 | |
| SCHEMBL7484521 | 0.67 | PDE3B (0.46) | PDE3BPDE3AKMT2APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329070-B1 | Cardiotonic alkanoyl and aroyl oxazolones | MERRELL DOW PHARMA (US) | 1994-01-05 | — | — | EP | disclosed |
| US-4866182-A | TREATMENT OF HEART FAILURE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-12 | — | — | US | disclosed |
| EP-0329070-A1 | Cardiotonic alkanoyl and aroyl oxazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-08-23 | — | — | EP | disclosed |