Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.32 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429835 | 0.81 | PDE3B (0.38) | PDE3BPDE3ACDC7GAACA1 | |
| SCHEMBL7272043 | 0.71 | PDE3B (0.43) | PDE3BPDE3ACDC7HPGDCYP1A2 | |
| SCHEMBL7425680 | 0.67 | PDE3B (0.43) | PDE3BPDE3ACDC7CYP2C9ALDH1A1 | |
| SCHEMBL28338028 | 0.63 | NAPRT (0.50) | CYP2C9GAACA1CA9ALDH1A1 | |
| SCHEMBL8846 | 0.63 | PDE3B (0.46) | PDE3BPDE3ACDC7ALDH1A1KDM4E | |
| Piroximone SCHEMBL119758 | 0.63 | PDE3B (1.00) | PDE3BPDE3ACYP2C9HSD17B10HPGD | |
| SCHEMBL10680196 | 0.62 | PDE3B (0.58) | PDE3BPDE3ACDC7CYP2C9KDM4E | |
| SCHEMBL9787143 | 0.62 | PDE3B (0.71) | PDE3BPDE3ACDC7CYP2C9KMT2A | |
| SCHEMBL10681806 | 0.59 | PDE3B (0.55) | PDE3BPDE3ACDC7CYP2C9ALDH1A1 | |
| SCHEMBL7276535 | 0.59 | LMNA (0.43) | GAAALDH1A1KDM4EPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4866182-A | TREATMENT OF HEART FAILURE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-12 | — | — | US | disclosed |
| EP-0329070-A1 | Cardiotonic alkanoyl and aroyl oxazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-08-23 | — | — | EP | disclosed |