SCHEMBL7429882

SCHEMBL7429882

CCC(N)(CC1CC1)c1cc(C)nc2c(-c3ccc(Cl)cc3Cl)c(C)nn12

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CRHR1 P34998 19/20 0.58
HTT P42858 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7441810 0.93 CRHR1 (0.52) CRHR1HTT
SCHEMBL7438135 0.85 CRHR1 (0.44) CRHR1HTT
SCHEMBL5599675 0.74 CRHR1 (1.00) CRHR1
SCHEMBL7429887 0.74 CRHR1 (0.56) CRHR1
SCHEMBL5599679 0.73 CRHR1 (0.55) CRHR1
SCHEMBL7434787 0.73 CRHR1 (0.57) CRHR1
SCHEMBL5599676 0.70 CRHR1 (0.58) CRHR1
SCHEMBL27670939 0.69 CRHR1 (0.52) CRHR1HTT
SCHEMBL5600192 0.69 CRHR1 (0.84) CRHR1
SCHEMBL16606731 0.67 CRHR1 (1.00) CRHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1149583-A2 Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues Pfizer Products Inc. (US) 2001-10-31 EP claimed