Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421697 | 0.85 | HPGD (0.57) | ALDH1A1HPGDAPEX1LMNAGAA | |
| SCHEMBL7426805 | 0.84 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4EAPEX1HSD17B10 | |
| SCHEMBL7892988 | 0.82 | NR1H4 (0.58) | ALDH1A1HPGDKDM4EAPEX1HSD17B10 | |
| SCHEMBL8200517 | 0.82 | SMN1; SMN2 (0.53) | ALDH1A1HPGDKDM4EAPEX1HSD17B10 | |
| SCHEMBL8210271 | 0.81 | KMT2A (0.57) | ALDH1A1APEX1HSD17B10LMNAL3MBTL1 | |
| SCHEMBL7886925 | 0.77 | POLB (0.52) | ALDH1A1KDM4EAPEX1HSD17B10LMNA | |
| SCHEMBL8206305 | 0.77 | NPC1 (0.48) | ALDH1A1KDM4EAPEX1HSD17B10LMNA | |
| SCHEMBL21014263 | 0.77 | HPGD (0.65) | ALDH1A1HPGDKDM4EUSP2APEX1 | |
| Bicarbonate SCHEMBL7886928 | 0.76 | POLB (0.48) | ALDH1A1KDM4EAPEX1HSD17B10LMNA | |
| SCHEMBL28475160 | 0.75 | NAMPT (0.63) | ALDH1A1HPGDLMNAGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934301-B1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 2001-06-20 | — | — | EP | disclosed |
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |
| EP-0934301-A1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998016521-A1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 1998-04-23 | — | — | WO | disclosed |