Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.66 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480538 | 0.99 | ADORA2A (0.65) | ADORA2AADORA1ALDH1A1 | |
| SCHEMBL7482833 | 0.88 | ADORA2A (0.56) | ADORA2AADORA1ADORA3 | |
| SCHEMBL6622137 | 0.81 | ADORA2A (0.68) | ADORA2AADORA1 | |
| SCHEMBL7705992 | 0.80 | HPGD (0.45) | ADORA2AALDH1A1ADORA3 | |
| SCHEMBL6863438 | 0.80 | ADORA2A (1.00) | ADORA2AADORA1ALDH1A1 | |
| SCHEMBL7709059 | 0.79 | SMN1; SMN2 (0.45) | ADORA2AALDH1A1ADORA3 | |
| SCHEMBL6870294 | 0.78 | ADORA2A (1.00) | ADORA2AADORA1ALDH1A1 | |
| SCHEMBL7427470 | 0.77 | ADORA2A (0.59) | ADORA2AADORA1 | |
| SCHEMBL7711835 | 0.76 | ADORA2A (0.64) | ADORA2A | |
| SCHEMBL7703248 | 0.76 | ADORA2A (0.46) | ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214322-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-19 | — | — | EP | claimed |
| WO-2001017999-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-15 | — | — | WO | claimed |
| EP-1214322-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-19 | — | — | EP | disclosed |
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |
| WO-2001017999-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-15 | — | — | WO | disclosed |