Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1233643 | 0.69 | RET (0.36) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL1234046 | 0.69 | RET (0.36) | PDE4APDE4BPDE4CPDE4DRET | |
| SCHEMBL1233518 | 0.69 | RET (0.38) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL20552850 | 0.68 | L3MBTL1 (0.63) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25966746 | 0.67 | HTR2C (0.35) | L3MBTL1KDM4EIDO1NPC1BRD4 | |
| SCHEMBL12844167 | 0.66 | GRM5 (0.40) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11723137 | 0.66 | KDM4E (0.51) | ALDH1A1L3MBTL1MAPTKDM4EHTT | |
| SCHEMBL25757544 | 0.64 | ELANE (0.47) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17461858 | 0.64 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL21297851 | 0.64 | L3MBTL1 (0.42) | L3MBTL1MAPTKDM4EHTTIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002062795-A9 | DIHYDROPYRAZOLOPYRIDINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | MITSUBISHI PHARMA CORP (JP) | 2002-10-10 | — | — | WO | disclosed |