Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434010 | 0.80 | TSHR (0.51) | MAPTKMT2AALDH1A1LMNAHTT | |
| SCHEMBL13574895 | 0.72 | NPSR1 (0.36) | MAPTKMT2AALDH1A1LMNAHTT | |
| SCHEMBL21514373 | 0.67 | KRAS (0.55) | KMT2AALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL7442010 | 0.65 | KDM4E (0.34) | MAPTKMT2AALDH1A1LMNAHTT | |
| SCHEMBL34462301 | 0.64 | MAPT (0.57) | MAPTKMT2AALDH1A1LMNAHTT | |
| SCHEMBL6743052 | 0.62 | ESR1 (0.49) | MAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL10231970 | 0.62 | KMT2A (0.49) | MAPTKMT2AALDH1A1LMNATP53 | |
| SCHEMBL3108332 | 0.62 | MEN1 (0.54) | MAPTKMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL22712548 | 0.61 | MAPT (0.58) | MAPTKMT2AALDH1A1LMNATP53 | |
| SCHEMBL22712456 | 0.61 | MAPT (0.58) | MAPTKMT2AALDH1A1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618207-B1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PROD (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0863143-A1 | Intermediates useful in the production of pyridopyrimidone angiotensin AII antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-09 | — | — | EP | disclosed |
| US-5466692-A | Substituted pyridopyrimidines and antihypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-14 | — | — | US | disclosed |
| EP-0618207-A1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-10-05 | — | — | EP | disclosed |