Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13574895 | 0.87 | NPSR1 (0.36) | KDM4ENPSR1LMNAALDH1A1MAPT | |
| SCHEMBL12575834 | 0.79 | LMNA (0.51) | KDM4ENPSR1LMNAALDH1A1MAPT | |
| SCHEMBL10004608 | 0.72 | SMN1; SMN2 (0.47) | KDM4ENPSR1LMNAALDH1A1MAPT | |
| SCHEMBL3098529 | 0.67 | PTGS1 (0.34) | KDM4ENPSR1LMNAALDH1A1MAPT | |
| SCHEMBL15237175 | 0.67 | ALDH1A1 (0.47) | KDM4ENPSR1LMNAALDH1A1MAPT | |
| SCHEMBL10073316 | 0.67 | PDE4D (0.55) | KDM4ENPSR1LMNAALDH1A1MAPT | |
| SCHEMBL31543156 | 0.67 | ALDH1A1 (0.35) | NPSR1ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL17035513 | 0.67 | CYP1A2 (0.36) | KDM4ENPSR1ALDH1A1MAPTNPC1 | |
| SCHEMBL27560431 | 0.66 | GLP1R (0.41) | KDM4ENPSR1LMNAALDH1A1MAPT | |
| SCHEMBL4288762 | 0.66 | ALDH1A1 (0.34) | KDM4EALDH1A1SMN1; SMN2GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618207-B1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PROD (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0863143-A1 | Intermediates useful in the production of pyridopyrimidone angiotensin AII antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-09 | — | — | EP | disclosed |
| US-5466692-A | Substituted pyridopyrimidines and antihypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-14 | — | — | US | disclosed |
| EP-0618207-A1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-10-05 | — | — | EP | disclosed |