Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430534 | 0.80 | MAPT (0.43) | NPSR1ALDH1A1MAPTLMNAHTT | |
| SCHEMBL6653181 | 0.77 | AGTR1 (0.46) | ALDH1A1NPC1RAB9AHTTKMT2A | |
| SCHEMBL6651290 | 0.74 | AGTR1 (0.41) | ALDH1A1NPC1RAB9AHTTKMT2A | |
| SCHEMBL6650864 | 0.74 | TP53 (0.51) | NPSR1ALDH1A1MAPTLMNARAD52 | |
| SCHEMBL7443188 | 0.72 | TSHR (0.42) | TSHRNPSR1ALDH1A1USP2ALOX15 | |
| SCHEMBL7653573 | 0.67 | APP (0.52) | NPSR1ALDH1A1LMNARAD52HTT | |
| SCHEMBL6743052 | 0.66 | ESR1 (0.49) | ALDH1A1MAPTUSP2ALOX15MAPK1 | |
| SCHEMBL4920880 | 0.65 | NPC1 (0.64) | TSHRNPSR1ALDH1A1MAPTLMNA | |
| SCHEMBL7649849 | 0.64 | KMT2A (0.55) | ALDH1A1MAPTLMNARAD52HTT | |
| SCHEMBL540769 | 0.64 | HDAC1 (0.65) | ALDH1A1MAPTLMNARAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618207-B1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PROD (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0863143-A1 | Intermediates useful in the production of pyridopyrimidone angiotensin AII antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-09 | — | — | EP | disclosed |
| US-5466692-A | Substituted pyridopyrimidines and antihypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-14 | — | — | US | disclosed |
| EP-0618207-A1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-10-05 | — | — | EP | disclosed |