Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.62 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10470912 | 0.79 | HSD11B1 (0.59) | HSD11B1POLBKMT2AALDH1A1HPGD | |
| SCHEMBL7306147 | 0.77 | MAPT (0.50) | HSD11B1POLBKMT2AALDH1A1HPGD | |
| SCHEMBL10469336 | 0.73 | HSD11B1 (0.48) | HSD11B1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL14006043 | 0.72 | HSD11B1 (0.83) | HSD11B1CRHR1KMT2AALDH1A1HPGD | |
| SCHEMBL16202037 | 0.71 | NPC1 (0.56) | HSD11B1CRHR1KMT2AALDH1A1HPGD | |
| SCHEMBL14996550 | 0.71 | HSD11B1 (0.54) | HSD11B1CRHR1KMT2AALDH1A1HPGD | |
| SCHEMBL2747350 | 0.70 | HSD11B1 (0.83) | HSD11B1 | |
| SCHEMBL14996580 | 0.70 | HSD11B1 (0.53) | HSD11B1CRHR1NPC1 | |
| SCHEMBL14996667 | 0.70 | HSD11B1 (0.53) | HSD11B1CRHR1 | |
| SCHEMBL14996575 | 0.70 | HSD11B1 (0.53) | HSD11B1CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4775688-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-04 | — | — | US | claimed |
| US-4775688-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0221485-A1 | 5-Aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-05-13 | — | — | EP | disclosed |