Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.41 |
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485829 | 0.85 | LMNA (0.50) | MAPTLMNAAPOBEC3GTDP1SMN1; SMN2 | |
| SCHEMBL7299383 | 0.81 | ALDH1A1 (0.43) | MAPTLMNAAPOBEC3GTDP1ALDH1A1 | |
| SCHEMBL7298467 | 0.81 | NR1H2 (0.48) | MAPTNR1H2NR1H3HSD11B1APOBEC3G | |
| SCHEMBL10469336 | 0.81 | HSD11B1 (0.48) | MAPTHSD11B1LMNAAPOBEC3GALDH1A1 | |
| SCHEMBL9259478 | 0.79 | NOTUM (0.50) | MAPTNR1H2NR1H3HSD11B1LMNA | |
| SCHEMBL9833680 | 0.79 | MEN1 (0.42) | MAPTLMNATDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10469500 | 0.79 | HTT (0.46) | MAPTLMNAAPOBEC3GGFERTDP1 | |
| SCHEMBL7430670 | 0.77 | HSD11B1 (0.62) | MAPTHSD11B1LMNAALDH1A1KMT2A | |
| SCHEMBL7435538 | 0.77 | GRM5 (0.38) | MAPTAPOBEC3GSMN1; SMN2NOTUMALDH1A1 | |
| SCHEMBL10669541 | 0.73 | TDP2 (0.46) | MAPTHSD11B1LMNATDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4912095-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones useful as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-27 | — | — | US | claimed |
| EP-0358150-A2 | Use of 5-(4-Chlorophenyl)-2,4-Dimethyl-3H-1,2,4-Triazole-3-thione for preparing drugs for the treatment of thrombocytosis | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-14 | — | — | EP | claimed |
| US-4847276-A | CARDIOVASCULAR DISORDERS | MERRELL DOW PHARMACEUTICALS INC. | 1989-07-11 | — | — | US | claimed |
| US-4775688-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-04 | — | — | US | claimed |
| EP-0221485-A1 | 5-Aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-05-13 | — | — | EP | claimed |
| JP-2115123-A | — | — | None | — | — | JP | disclosed |
| US-5723624-A | Process for the preparation of 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones | MERRELL PHARMACEUTICALS INC (US) | 1998-03-03 | — | — | US | disclosed |
| EP-0769009-A1 | PROCESS FOR THE PREPARATION OF 5-ARYL-2,4-DIALKYL-3H-1,2,4-TRIAZOLE-3-THIONES | MERRELL PHARMACEUTICALS INC. (US) | 1997-04-23 | — | — | EP | disclosed |
| EP-0452926-B1 | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers | MERRELL DOW PHARMA (US) | 1996-03-13 | — | — | EP | disclosed |
| WO-1996001812-A1 | PROCESS FOR THE PREPARATION OF 5-ARYL-2,4-DIALKYL-3H-1,2,4-TRIAZOLE-3-THIONES | MERRELL PHARMACEUTICALS INC. (US) | 1996-01-25 | — | — | WO | disclosed |
| US-5331002-A | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enhancers | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-07-19 | — | — | US | disclosed |
| US-5236942-A | 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful in the treatment of Altzheimer's dementia | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-17 | — | — | US | disclosed |
| US-4912095-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones useful as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0358150-A2 | Use of 5-(4-Chlorophenyl)-2,4-Dimethyl-3H-1,2,4-Triazole-3-thione for preparing drugs for the treatment of thrombocytosis | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-14 | — | — | EP | disclosed |
| EP-0358150-A2 | Use of 5-(4-Chlorophenyl)-2,4-Dimethyl-3H-1,2,4-Triazole-3-thione for preparing drugs for the treatment of thrombocytosis | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-14 | — | — | EP | disclosed |
| US-4847276-A | CARDIOVASCULAR DISORDERS | MERRELL DOW PHARMACEUTICALS INC. | 1989-07-11 | — | — | US | disclosed |
| US-4847276-A | CARDIOVASCULAR DISORDERS | MERRELL DOW PHARMACEUTICALS INC. | 1989-07-11 | — | — | US | disclosed |
| US-4775688-A | 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0280867-A1 | Process for the preparation of 5-aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-09-07 | — | — | EP | disclosed |
| EP-0221485-A1 | 5-Aryl-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-05-13 | — | — | EP | disclosed |