SCHEMBL7430780

SCHEMBL7430780

O=C(O)NC(Cc1ccccc1)[C@@H](O)CN(OC1CCCCC1)S(=O)(=O)c1ccc(O)cc1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MLNR O43193 1/20 0.44
ABCB11 O95342 1/20 0.44
LMNA P02545 1/20 0.44
CTSD P07339 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP3A5 P20815 1/20 0.44
CNR1 P21554 1/20 0.44
TBXAS1 P24557 1/20 0.44
ADRA1A P35348 1/20 0.44
SPPL2A Q8TCT8 1/20 0.41
ABCB1 P08183 1/20 0.40
KCNE1 P15382 1/20 0.40
KCNQ1 P51787 1/20 0.40
KCNH2 Q12809 1/20 0.40
SCN5A Q14524 1/20 0.40
KCND3 Q9UK17 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4872903 1.00 MLNR (0.44) MLNRABCB11LMNACTSDCYP3A4
SCHEMBL7430773 1.00 MLNR (0.44) MLNRABCB11LMNACTSDCYP3A4
SCHEMBL4872912 1.00 MLNR (0.44) MLNRABCB11LMNACTSDCYP3A4
SCHEMBL4875375 0.93 CTSD (0.52) MLNRABCB11LMNACTSDCYP3A4
SCHEMBL4875377 0.93 CTSD (0.52) MLNRABCB11LMNACTSDCYP3A4
SCHEMBL4869483 0.91 ADAMTS4 (0.43) MLNRABCB11LMNACTSDCYP3A4
SCHEMBL4869489 0.91 ADAMTS4 (0.43) MLNRABCB11LMNACTSDCYP3A4
SCHEMBL4862405 0.90 CTSD (0.44) MLNRABCB11LMNACTSDCYP3A4
SCHEMBL4862414 0.90 CTSD (0.44) MLNRABCB11LMNACTSDCYP3A4
SCHEMBL7430295 0.89 MLNR (0.42) MLNRABCB11LMNACTSDCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1086076-A1 SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE Vertex Pharmaceuticals Incorporated (US) 2001-03-28 EP disclosed
WO-1999065870-A2 SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE VERTEX PHARMACEUTICALS INCORPORATED (US) 1999-12-23 WO disclosed