⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10597224 | 0.83 | — | — | |
| SCHEMBL10599698 | 0.80 | OPRM1 (0.32) | — | |
| SCHEMBL27607086 | 0.80 | — | — | |
| SCHEMBL5185260 | 0.79 | — | — | |
| SCHEMBL13281319 | 0.78 | TSHR (0.32) | — | |
| SCHEMBL27467887 | 0.78 | USP2 (0.35) | — | |
| SCHEMBL27845632 | 0.78 | — | — | |
| SCHEMBL6195587 | 0.78 | KDM1A (0.32) | — | |
| SCHEMBL7427190 | 0.77 | RARA (0.30) | — | |
| SCHEMBL7201534 | 0.77 | NR5A1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118324596-A | Synthesis method of biaryl compound | 新疆大学 | 2024-07-12 | — | — | CN | disclosed |
| CN-117510491-A | Compounds and methods for rapid accelerated targeted degradation of fibrosarcoma polypeptides | 阿尔维纳斯运营股份有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-110741004-B | Compounds and methods for rapid accelerated targeted degradation of fibrosarcoma polypeptides | 阿尔维纳斯运营股份有限公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-114206843-A | Compounds for modulating proprotein convertase subtilisin/Kexin type 9(PCSK9) | SRX心脏有限责任公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-113164775-A | Polycyclic compounds and methods for rapid accelerated targeted degradation of fibrosarcoma polypeptides | 阿尔维纳斯运营股份有限公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-109456301-B | Crown ether-containing HBC compound and preparation and application thereof | 东华大学 | 2021-07-02 | — | — | CN | disclosed |
| CN-110741004-A | Compounds and methods for rapid accelerated targeted degradation of fibrosarcoma polypeptides | 阿尔维纳斯运营股份有限公司 | 2020-01-31 | — | — | CN | disclosed |
| CN-102382036-A | Phenoxyacetic acid compound, preparation method thereof and drug application | INST MATERIA MEDICA CAMS | 2012-03-21 | — | — | CN | disclosed |
| CN-101558509-B | Composition for organic device, polymer film, and organic electroluminescent element | MITSUBISHI CHEM CORP | 2011-11-16 | — | — | CN | disclosed |
| CN-102066337-A | 5-hydroxypyrimidine-4-carboxamide compounds | DAIICHI SANKYO CO LTD | 2011-05-18 | — | — | CN | disclosed |
| CN-101563089-A | Boronic acids and esters as inhibitors of fatty amide hydrolase | INFINITY DISCOVERY INC (US) | 2009-10-21 | — | — | CN | disclosed |
| CN-101558509-A | Composition for organic device, polymer film, and organic electroluminescent element | MITSUBISHI CHEM CORP (JP) | 2009-10-14 | — | — | CN | disclosed |
| CN-1582287-A | Thiophenylthiopyrane dioxides as MMP or TNF-alpha inhibitors | FUJISAWA PHARMACEUTICAL CO (JP) | 2005-02-16 | — | — | CN | disclosed |
| CN-1157376-C | Arylpiperidinopropanol and arylpiperazinopropanol derivatives and drugs containing the same | ��һ��������ҩ��ʽ���� | 2004-07-14 | — | — | CN | disclosed |
| CN-1246110-A | Arylpiperidinopropanol and arylpiperazinopropanol derivatives and drugs containing the same | SUNTORY LTD (JP) | 2000-03-01 | — | — | CN | disclosed |
| EP-0958280-A1 | ARYLPIPERIDINOPROPANOL AND ARYLPIPERAZINOPROPANOL DERIVATIVES AND PHARMACEUTICALS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1999-11-24 | — | — | EP | disclosed |
| WO-1999023072-A1 | ARYLPIPERIDINOPROPANOL AND ARYLPIPERAZINOPROPANOL DERIVATIVES AND PHARMACEUTICALS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1999-05-14 | — | — | WO | disclosed |