Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.58 |
| ▸ | ACE | P12821 | 1/20 | 0.55 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.53 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.52 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6369971 | 0.89 | ACE (0.67) | ACECTSSCTSLCTSBCTSK | |
| SCHEMBL22962260 | 0.87 | REN (0.61) | RENACEPSMB5PSEN1PSEN2 | |
| SCHEMBL25378366 | 0.87 | PTPN1 (0.54) | ACEPSMB5PSMB1PSMB2CTSS | |
| SCHEMBL25378369 | 0.87 | PTPN1 (0.54) | ACEPSMB5PSMB1PSMB2CTSS | |
| SCHEMBL22962329 | 0.86 | REN (0.61) | RENACEPSMB5PSEN1PSEN2 | |
| SCHEMBL20516080 | 0.86 | REN (0.61) | RENACEPSMB5PSEN1PSEN2 | |
| SCHEMBL20669327 | 0.86 | REN (0.61) | RENACEPSMB5PSEN1PSEN2 | |
| SCHEMBL28617007 | 0.86 | REN (0.61) | RENACEPSMB5PSEN1PSEN2 | |
| SCHEMBL28617005 | 0.86 | REN (0.61) | RENACEPSMB5PSEN1PSEN2 | |
| SCHEMBL30559600 | 0.86 | CHRNB2 (0.57) | PSMB5PSMB1PSMB2CTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4981843-A | HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1991-01-01 | — | — | US | disclosed |
| EP-0337295-A2 | Renin-inhibiting N-heterocyclic dipeptides | E.R. Squibb & Sons, Inc. (US) | 1989-10-18 | — | — | EP | disclosed |