Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3058689 | 0.86 | MAPT (0.50) | MAPTL3MBTL1MAPK1TDP1MAOB | |
| SCHEMBL6195407 | 0.78 | MAOB (0.51) | MAPTL3MBTL1MAPK1TDP1MAOB | |
| SCHEMBL27556138 | 0.78 | MAOB (0.52) | MAPTL3MBTL1MAPK1TDP1MAOB | |
| SCHEMBL17260912 | 0.78 | MAPT (0.43) | MAPTL3MBTL1MAPK1TDP1MAOB | |
| SCHEMBL7285346 | 0.78 | L3MBTL1 (0.52) | MAPTL3MBTL1MAPK1TDP1MAOB | |
| SCHEMBL17260899 | 0.78 | MAPT (0.43) | MAPTL3MBTL1MAPK1TDP1MAOB | |
| SCHEMBL27716272 | 0.78 | LMNA (0.48) | MAPTL3MBTL1MAPK1TDP1MAOB | |
| SCHEMBL27584953 | 0.75 | MAOB (0.50) | MAPTL3MBTL1MAPK1TDP1MAOB | |
| SCHEMBL27898562 | 0.75 | MAPT (0.44) | MAPTL3MBTL1MAPK1TDP1MAOB | |
| SCHEMBL9199334 | 0.74 | NR4A2 (0.47) | MAOBLMNACYP1A2PTGS1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760048-A | TREATMENT OF STROKE AND NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 1998-06-02 | — | — | US | claimed |
| US-5760048-A | TREATMENT OF STROKE AND NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 1998-06-02 | — | — | US | disclosed |
| US-5554767-A | NERVOUS SYSTEM, CARDIOVASCULAR, AND BRAIN DISORDERS | WARNER-LAMBERT COMPANY (US) | 1996-09-10 | — | — | US | disclosed |