Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | CTSV | O60911 | 3/20 | 0.49 |
| ▸ | CTSL | P07711 | 3/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9392551 | 0.81 | SLC22A6 (0.53) | CYP1A2GAAKDM4EALDH1A1HPGD | |
| SCHEMBL9389924 | 0.79 | HPGD (0.59) | KDM4EALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL9393341 | 0.79 | GRIN2D (0.46) | CYP1A2KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL7802847 | 0.79 | LMNA (0.59) | KDM4EALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL9389039 | 0.79 | PARP1 (0.51) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL250338 | 0.79 | BRD4 (0.59) | GAAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL31398830 | 0.79 | BRD4 (0.59) | GAAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3423473 | 0.78 | DAO (0.61) | CYP1A2KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL26847033 | 0.78 | HPGD (0.63) | CYP1A2GAAKDM4EALDH1A1HPGD | |
| SCHEMBL3418597 | 0.77 | DAO (0.59) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644878-B1 | 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-09-12 | — | — | EP | disclosed |
| US-5801168-A | NMDA RECEPTOR ANTAGONISTS | ZENECA LIMITED (GB) | 1998-09-01 | — | — | US | disclosed |
| EP-0702673-B1 | BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | disclosed |
| US-5712272-A | TREATMENT OF NEUROLOGICAL DISORDERS WITH BENZ(B)AZEPINE COMPOUNDS | ZENECA LIMITED (GB) | 1998-01-27 | — | — | US | disclosed |
| US-5708168-A | FOR TREATING OR PREVENTING NEURONAL LOSS | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON, EUGENE OREGON (US) | 1998-01-13 | — | — | US | disclosed |
| US-5656626-A | NERVOUS SYSTEM OR BRAIN DISORDERS; BENZ(B)AZEPINE | ZENECA LIMITED (GB) | 1997-08-12 | — | — | US | disclosed |
| US-5654295-A | NEUROLOGICAL DISORDERS; BENZ(B0AZEPINE COMPOUNDS | ZENECA LIMITED (GB) | 1997-08-05 | — | — | US | disclosed |
| WO-1996015112-A1 | AZEPINE SYNTHESIS VIA A DIELS-ALDER REACTION | ACEA PHARMACEUTICALS, INC. (US) | 1996-05-23 | — | — | WO | disclosed |
| EP-0702673-A1 | BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | ZENECA LIMITED (GB) | 1996-03-27 | — | — | EP | disclosed |
| US-5502048-A | CNS, STROKES, HYPOGLYCEMIC AGENTS AND ANTIISCHEMIC AGENTS | ZENECA LIMITED (GB) | 1996-03-26 | — | — | US | disclosed |
| US-5476933-A | Condensation, ring expansion | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON (US) | 1995-12-19 | — | — | US | disclosed |
| US-5446039-A | Treating nervous system and brain disorder, acting as excitatory amino acid antagonist | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1995-08-29 | — | — | US | disclosed |
| EP-0644878-A1 | 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS | ZENECA LIMITED (GB) | 1995-03-29 | — | — | EP | disclosed |
| WO-1994029275-A1 | BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | ZENECA LIMITED (GB) | 1994-12-22 | — | — | WO | disclosed |
| WO-1994007500-A1 | 2,5-DIHYDRO-2,5-DIOXO-1H-AZEPINES AND 2,5-DIHYDRO-2-OXO-1H-AZEPINES AND THE USE THEREOF AS EXCITATORY AMINO ACID AND GLYCINE RECEPTOR ANTAGONISTS | WEBER ECKARD (US) | 1994-04-14 | — | — | WO | disclosed |
| WO-1993025534-A1 | 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ[b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS | ZENECA LIMITED (GB) | 1993-12-23 | — | — | WO | disclosed |
| US-4575503-A | ANGIOTENSIN CONVERTING ENZYME INHIBITOR, HYPOTENSIVE | CIBA-GEIGY CORPORATION (US) | 1986-03-11 | — | — | US | disclosed |
| US-4473575-A | ANGIOTENSIN INHIBITORS, HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1984-09-25 | — | — | US | disclosed |
| US-4410520-A | ANGIOTENSION CONVERTING ENZYME INGIBITOR, HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1983-10-18 | — | — | US | disclosed |
| EP-0072352-A1 | Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and the compounds for therapeutical use | CIBA-GEIGY AG (CH) | 1983-02-16 | — | — | EP | disclosed |