Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.83 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.83 |
| ▸ | TSHR | P16473 | 1/20 | 0.83 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 3/20 | 0.58 |
| ▸ | DRD5 | P21918 | 3/20 | 0.58 |
| ▸ | DRD3 | P35462 | 3/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 2/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3383921 | 0.94 | KDM4E (0.78) | KDM4EALOX15TSHRSIRT1ALDH1A1 | |
| SCHEMBL13593314 | 0.94 | KDM4E (0.78) | KDM4EALOX15TSHRSIRT1ALDH1A1 | |
| SCHEMBL31188916 | 0.91 | KDM4E (1.00) | KDM4EALOX15TSHRSIRT1ALDH1A1 | |
| SCHEMBL315339 | 0.91 | KDM4E (1.00) | KDM4EALOX15TSHRSIRT1ALDH1A1 | |
| SCHEMBL7997184 | 0.88 | KDM4E (0.68) | KDM4EALOX15TSHRSIRT1ALDH1A1 | |
| SCHEMBL11347453 | 0.84 | HDAC3 (0.65) | KDM4EALOX15TSHRSIRT1HPGD | |
| SCHEMBL9375738 | 0.83 | KDM4E (0.65) | KDM4EALOX15TSHRSIRT1ALDH1A1 | |
| SCHEMBL7995733 | 0.82 | HDAC6 (0.67) | KDM4EALOX15TSHRSIRT1ALDH1A1 | |
| SCHEMBL30073110 | 0.82 | KDM4E (0.72) | KDM4EALOX15TSHRSIRT1ALDH1A1 | |
| SCHEMBL30073106 | 0.82 | KDM4E (0.72) | KDM4EALOX15TSHRSIRT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375451-A2 | Compounds having a renin-inhibiting activity | BEECHAM GROUP PLC (GB) | 1990-06-27 | — | — | EP | disclosed |