Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.67 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.67 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.67 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.67 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.67 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.67 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.65 |
| ▸ | HTR7 | P34969 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | DRD5 | P21918 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7997184 | 0.94 | KDM4E (0.68) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3785757 | 0.90 | KDM4E (0.75) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13593314 | 0.89 | KDM4E (0.78) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3383921 | 0.89 | KDM4E (0.78) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7433345 | 0.82 | KDM4E (0.83) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL24437908 | 0.82 | KDM4E (0.63) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20329971 | 0.81 | HTR7 (0.61) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13910341 | 0.81 | HTR7 (0.61) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9375915 | 0.81 | HTR7 (0.61) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL18612248 | 0.81 | HTR7 (0.61) | HDAC6HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010014554-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORPORATION (US) | 2010-02-04 | — | — | WO | disclosed |
| WO-2009117150-A2 | METHOD OF TREATING LUPUS WITH CERAMIDE DERIVATIVES | GENZYME CORPORATION (US) | 2009-09-24 | — | — | WO | disclosed |