Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD5 | P21918 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31188916 | 1.00 | KDM4E (1.00) | KDM4EALOX15TSHRSIRT1HTR1A | |
| SCHEMBL7433345 | 0.91 | KDM4E (0.83) | KDM4EALOX15TSHRSIRT1HTR1A | |
| SCHEMBL3383921 | 0.88 | KDM4E (0.78) | KDM4EALOX15TSHRSIRT1HTR1A | |
| SCHEMBL13593314 | 0.88 | KDM4E (0.78) | KDM4EALOX15TSHRSIRT1HTR1A | |
| SCHEMBL3785757 | 0.86 | KDM4E (0.75) | KDM4EALOX15TSHRSIRT1HTR1A | |
| SCHEMBL15233568 | 0.86 | KDM4E (0.75) | KDM4EALOX15TSHRSIRT1HTR1A | |
| SCHEMBL15690262 | 0.84 | KDM4E (0.73) | KDM4EALOX15TSHRSIRT1DRD2 | |
| SCHEMBL30073110 | 0.84 | KDM4E (0.72) | KDM4EALOX15TSHRSIRT1HTR1A | |
| SCHEMBL30073106 | 0.84 | KDM4E (0.72) | KDM4EALOX15TSHRSIRT1HTR1A | |
| SCHEMBL29676908 | 0.83 | KDM4E (0.71) | KDM4EALOX15TSHRSIRT1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10813934-B2 | Sirtuin modulators as inhibitors of cytomegalovirus | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2020-10-27 | — | — | US | disclosed |
| US-20160296523-A1 | Sirtuin Modulators as Inhibitors of Cytomegalovirus | THE TRUSTEES OF PRINCETON UNIVERSITY | 2016-10-13 | — | — | US | disclosed |
| US-20160296523-A1 | Sirtuin Modulators as Inhibitors of Cytomegalovirus | THE TRUSTEES OF PRINCETON UNIVERSITY | 2016-10-13 | — | — | US | disclosed |
| US-8999974-B2 | Acyl piperazine derivatives as TTX-S blockers | RAQUALIA PHARMA INC. (JP) | 2015-04-07 | — | — | US | disclosed |
| US-8999974-B2 | Acyl piperazine derivatives as TTX-S blockers | RAQUALIA PHARMA INC. (JP) | 2015-04-07 | — | — | US | disclosed |
| US-8993718-B2 | Methods and compositions for detecting and modulating O-glycosylation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-03-31 | — | — | US | disclosed |
| US-8993718-B2 | Methods and compositions for detecting and modulating O-glycosylation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-03-31 | — | — | US | disclosed |
| US-20140187444-A1 | METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140187444-A1 | METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-07-03 | — | — | US | disclosed |
| US-8524444-B2 | Methods and compositions for detections and modulating O-glycosylation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-09-03 | — | — | US | disclosed |
| US-20090326007-A1 | Compounds and methods for modulating sir2 protein activity | THE WISTAR INSTITUTE | 2009-12-31 | — | — | US | disclosed |
| US-20090326007-A1 | Compounds and methods for modulating sir2 protein activity | THE WISTAR INSTITUTE | 2009-12-31 | — | — | US | disclosed |
| US-20090326007-A1 | Compounds and methods for modulating sir2 protein activity | THE WISTAR INSTITUTE | 2009-12-31 | — | — | US | disclosed |
| WO-2008156676-A1 | METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2008-12-24 | — | — | WO | disclosed |
| US-20080305496-A1 | Method for identifying a compound that modulates SIR2 protein activity | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-11 | — | — | US | disclosed |
| US-20080305496-A1 | Method for identifying a compound that modulates SIR2 protein activity | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-11 | — | — | US | disclosed |
| CN-1898244-A | Triazole derivatives as vasopressin antagonists | PFIZER (US) | 2007-01-17 | — | — | CN | disclosed |
| EP-1701959-A1 | TRIAZOLE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | Pfizer Limited (GB) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005063754-A1 | TRIAZOLE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | PFIZER LIMITED (GB) | 2005-07-14 | — | — | WO | disclosed |
| US-20050154024-A1 | Compounds useful in therapy | PFIZER INC | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10813934-B2 | Sirtuin modulators as inhibitors of cytomegalovirus | SIRT1, SIRT2, SIRT7 | KDM4E 700/4885ALOX15 4803/4885TSHR 4049/4885 |
| US-20160296523-A1 | Sirtuin Modulators as Inhibitors of Cytomegalovirus | SIRT1, SIRT2, SIRT7 | KDM4E 700/4885ALOX15 4803/4885TSHR 4049/4885 |
| US-20050154024-A1 | Compounds useful in therapy | PTGER4, PTGER3, ALOX5 | KDM4E 3377/4885ALOX15 23/4885TSHR 577/4885 |
| US-20090326007-A1 | Compounds and methods for modulating sir2 protein activity | SIRT2, SIRT1, SIRT3 | KDM4E 816/4885ALOX15 4627/4885TSHR 4506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.